McGinnis Lab — Data

Reports

• GBM snATAC enhancer atlas — top-1000 per cell type (v4)
  48 patients × 8 cohorts × 1.52 M nuclei. 14 cell-type tabs with row-expansion panels showing per-patient fragments-per-cell and per-cohort detection. Candidate enhancer regions for AAV-driven selective expression.
  v4 · 2026-10-17
  Underlying h5ad (per-cell integrated matrices)

  gbm_atlas_v1.1_cxg.h5ad — 112 GB · CELLxGENE-formatted (cell_type ontology, obs/var standardized, raw+normalized layers)

  gbm_atlas_v1.1_integrated.h5ad — 96 GB · raw integrated (per-cell × union peak matrix, pre-CXG schema)

  Direct download link pending AWS Open Data Sponsorship review (PR #3433). Will update here once approved. For early access, email mcginnislab.
• Normal brain snATAC enhancer atlas — top-1000 per cell type (v3)
  Up to 830 donors × 25 cohorts in abundant cell types (OPC 830 / Oligo 745 / Inhibitory 704 / Astrocyte 704 / Microglia 661 / Excitatory 528 / Endothelial 362); rare types (Meninges, T_cell, Serotonergic, Dopaminergic) have single-digit to ~20 donors. 41 M barcodes (6 M post nnz≥1k QC) × 990 K union peaks. 16 major cell-type tabs with per-cohort replication and surgical/postmortem split, Design B narrow sub-peaks (median ~518 bp) rendered inline for AAV cloning, direct UCSC Genome Browser deep links.
  v3 · 2026-10-24
  Underlying h5ad (per-cell integrated matrix)

  nb_atlas_v1.1_integrated.h5ad — 342 GB · raw integrated (per-cell × union peak matrix, 16 major_class labels, 23-cohort provenance in obs)

  Direct download link pending AWS Open Data Sponsorship review (PR #3433). Will update here once approved. For early access, email mcginnislab.